Pr. Dr. Patrizia Anna D'Alessio
MD (University of Milan) · PhD (Utrecht University) · Associate Professor of Cellular Biology (Paris 5 & Paris 11, 1998–2012, HDR 2000) · CEO AISA Therapeutics (2005-2026)
A physician specialized in internal medicine and hematology, with a doctorate in hemorheology, and a professor of cellular biology for 15 years in the medical faculties of Paris, Patrizia D’Alessio is a globally recognized expert in the molecular mechanisms of inflammation, stress, and the biology of aging.
Her work focuses on cellular senescence and its reversibility, as well as the role of inflammatory markers, leading to the identification of a non-toxic anti-inflammatory molecule derived from a bio-guided research on more than 2,000 plant extracts. She founded AISA Therapeutics in 2005, holder of 3 international patents (Europe, USA, China).
Years of research
International patents
Plant extracts studied
Academic background
& institutional
1984 – 1989
Doctor of Medicine (MD)
Medical studies at the University of Milan (Italy), with specialization in internal medicine and clinical and laboratory hematology.
1985 – 1989
Postdoctoral Research in Cellular Biology (PhD)
Doctorate in hemorheology, studying the flow properties of blood and its cellular components, under the supervision of Prof. Jan J. Sixma, Academic Hospital, Utrecht University.
1990 – 1992
Postdoctoral Research in Free Radical Chemistry
Postdoctoral research at King’s College London, focusing on the molecular mechanisms of oxidative stress.
1992 – 1998
Academic Researcher in collaboration with INSERM & CNRS
Continued research in cellular biology within INSERM (Paris René Descartes) and CNRS (Gif-sur-Yvette) teams, focusing on replicative senescence, its reversibility, and aging.
1998 – 2012
Professor of Cellular Biology
HDR (Habilitation to Supervise Research, 2000), appointed Professor of Cellular Biology in the Faculties of Medicine at the University Paris René Descartes (Paris 5, 1998-2002) and University Paris Sud-11 (2003-2012). Teaching and leading research on chronic inflammation and aging.
2003 – 2008
Co-Director, Shanghai Research Group
Co-directed with George Uzan in the team of Dr. Deng-hai Zhang at Fudan University in Shanghai, in collaboration with Pudong Gongli Hospital. Research on AISA analogues and preclinical validation.
2009 – 2013
Co-director of the European FP7 RISTOMED Consortium
Scientific co-director of the European consortium RISTOMED («Healthy aging by nutrition»), funded by the European Union’s 7th Framework Programme. First in human clinical validation of AISA actives.
2005 – Present
CEO & Founder — AISA Therapeutics
Founded and led AISA Therapeutics, a company dedicated to the development and commercialization of anti-inflammatory and anti-senescence nutraceutical, cosmeceutical, and pharmaceutical products.
Patents & Scientific
Publications
Anti-Inflammatory Senescence Actives (AISA) — terpenoids monoterpenes and d-Limonene
Filed : 2005–2008
Regions: Europe, États-Unis, Chine
Incumbents : AISA Therapeutics, Patrizia A. d'Alessio
Salutogenesis and beyond
Journal : Dermatologic Therapy (Wiley)
Year : 2019
Author : Patrizia A. d'Alessio
DOI : 10.1111/dth.12783
Impact of diet and nutraceutical supplementation on inflammation in elderly people — RISTOMED Study
Type : Open-label randomized control trial
Consortium : FP7 European Commission
Period : 2009–2013
PI : Patrizia A. d'Alessio (co-directrice)
Markers of biological aging
Review : Correspondence in Oncology and Hematology
Year : 2018
Volume : 13, pp. 18–20
Author : d'Alessio, P. A.
Books & Contributions
Inflammation,
the body's warning system
Understanding and acting on the mechanisms of chronic inflammation
Dangles Publishing
2019
General public
A popular science book aimed at the general public, explaining the biological mechanisms of silent and chronic inflammation, its links to aging and disease, and notably how stress can induce a chronic irresolvable inflammatory status. For patients and doctors, promoted by experts in anti-aging medicine and longevity.
The Architecture of Life: From Plato to Tensegrity
Publisher : Brepols
Year : 2007
Type : A transdisciplinary anthology
The Sinuosity of Life
Publisher : Hermann
Year : 2012
Type : A transdisciplinary anthology
Awards & Distinctions
National Award for Innovative Business Creation
2005 · Ministry of Research (France) · Awarded for the creation of AISA Therapeutics and the promotion of fundamental scientific research in marketable products.
Appointment as Professor
1998 · Faculties of Medicine Paris 5 & Paris 11 · Recognition of the excellence of his research work in cell biology and his expertise in chronic inflammation and aging.
Co-director of the EU FP7 Consortium
2009–2013 · European Commission · Member of the RISTOMED consortium, a clinical research project on healthy aging through nutrition, funded under the 7th Framework Program.
3 International Patents Filed
2005–2008 · Europe, USA, China · Simultaneous intellectual property protection in three major geographical areas for discoveries relating to terpenoids, monoterpens and anti-inflammatory d-Limonene.
Research & Innovation
Preclinical and clinical studies, the molecular mechanisms of d-Limonene, the RISTOMED consortium, and the scientific advances that form the basis of each AISA formula.
Conferences & Masterclasses
Her presentations at global conferences on anti-aging medicine, healthy longevity and geroscience, as well as dermatology and aesthetic medicine—AMWC, IMCAS, 5CC World Congress, Tech for Longevity—and her masterclasses for professionals, Universities of Dresden, Barcelona, Lisboa.
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