From molecule to exceptional skincare
Three decades of fundamental research on inflammation and aging, condensed into patented, clinically validated molecular technology. This is the science behind every AISA Care formula.
Anti-inflammatory monoterpene d-Limonene
A natural asset,
a precise mechanism
D-limonene is a cyclic monoterpene, identified after a bio-guided research on more than 2,000 plant extracts that were screened and tested biologically for their capacity to reverse senescence and control the inflammatory facet of SASP. It is the most powerful, bioavailable, and non-toxic anti-inflammatory active at the identified doses. The same molecular sequence found in the original plant of the Vietnamese rain forest is found in cold-pressed organic orange peel extract.
Its mechanism of action targets pro-inflammatory cytokines in the bloodstream, thereby reducing the inflammatory cascade before it damages cells. By acting at the source, AISA d-Limonene stops premature senescence induced by oxidative stress and acts on senescent cells themselves, which are sources of pro-inflammatory load.
Measurable reduction in IL-6, IL-1β, and TNF-α cytokines
Improvement of the intestinal barrier (rebalanced microbiome)
Increased dopamine secretion (mood, motivation)
Anti-senescence action on cells under stress
Reversibility effect on senescent cells (senomorphic action)
Cold extraction, without solvents, guaranteeing maximum purity
Three patents
international
Anti-Inflammatory Senescence Actives (AISA)
d-Limonene Analogues
Intellectual property protection covering the use of monoterpens such as d-Limonene in the treatment and prevention of chronic inflammation, premature cellular senescence, and pathologies associated with aging. Now expired, a first application patent was also protecting the selection criteria adopted to ensure its maximum deployment in a broad range therapeutic applications. It will be re-filed as a formulation patent for nutraceutic interventions limited to chronic inflammatory diseases, cardio-metabolic diseases and neuro-degenerative diseases.
European FP7 RISTOMED
Consortium
First human clinical trial
As part of the RISTOMED consortium, Prof. Patrizia D’Alessio co-led a multicentric clinical study in collaboration with several European universities (Charité Berlin, Sapienza University of Rome, and CHU Arnozan in Bordeaux). The aim was to conduct the first randomized controlled clinical trial on the anti-inflammatory effects of dietary supplements, including AISA d-limonene, in healthy but inflamed older adults, both genders equally represented.
The study involved 138 participants, aged 65 to 85, presenting markers of chronic inflammation. For 12 weeks, one of the test groups received daily supplementation with AISA d-Limonene, while the control group followed a Mediterranean diet.
Significant reduction in pro-inflammatory cytokines in the blood (–48% IL-6, –42% TNF-α)
Significant reduction in cardiometabolic markers (fibrinogen, insulin, HOMA-IR, insulin resistance index)
Restoration of the intestinal barrier and rebalancing of the microbiota
Measurable improvement in quality of life and overall well-being
Reduction in perceived stress and improvement in mood (CES-D questionnaires measuring depression and anxiety)
No adverse side effects reported
Confirmed bioavailability and good tolerance
User Reviews
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Preclinical studies
& animal models
All animal studies were conducted by ethologists with the highest respect for animals and, in most cases, did not involve sacrificing the animal but rather a «wash-out» of the molecule.
Stress-induced systemic inflammation
Study on mice subjected to acute stress based on isolation. Daily administration of AISA d-limonene for 8 weeks, with dosing of all inflammatory markers as well as markers of the central and peripheral nervous system, particularly ortho-and-parasympathetic responses.
Oxidative stress-induced senescence
Cell culture of dermal endothelial cells exposed to inflammatory cytokines and treated with different concentrations of d-limonene to measure its anti-senescence effect on the SASP phenotype.
Improvement of the intestinal and skin barrier
In vitro model on human intestinal enterocytes. Supplementation with d-limonene with analysis of barrier integrity and tight junctions of the epithelium.
Neuroinflammation & dopamine
Study on a murine model of depression induced by chronic stress. Measurement of neurotransmitters and inflammatory markers in the central nervous system.
Behind the story of the founding of AISA Care lie two complementary worlds to explore.
Patrizia D'Alessio,
MD, PhD, Professor
Her entire scientific career: physician, cell biologist, professor at Paris 5 and 11, her publications, patents, books, and academic distinctions.
Conferences & Masterclasses
His presentations at global conferences on anti-aging medicine, dermatology, and longevity—IMCAS, 5CC World Congress, Tech for Longevity—and his masterclasses for professionals.
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